![]() ![]() Any clinically important comorbidities other than asthma (e.g.Documented treatment of nasal polyposis exacerbation with SCS for at least 3 consecutive days or one IM depo-injectable dose (or contraindications/intolerance to) within the past 12 months prior to Visit 1 but not within the last 3 months prior to Visit 1 and/or any history of NP surgery (or contraindications/intolerance to).Any standard of care for treatment of CRSwNP provided the participant is stable on that treatment for 30 days prior to Visit 1.SNOT-22 total score ≥ 30 at screening (Visit 1).Ongoing documented NP symptoms over > 8 weeks prior to screening such as rhinorrhea and/or reduction/loss of smell.Nasal Congestion Score (NCS) ≥ 2 at Visit 1.Severity consistent with need for surgery as defined by total NPS ≥ 5 (≥ 2 for each nostril) at screening, as determined by the central reader.Participants with physician-diagnosed CRSwNP for at least 12 months prior to Visit 1 that have: Resolution/Near Complete Resolution of Nasal Polyps (defined as maximum NPS of 1 in each nostril).A total symptom score is calculated by taking the sum of the 8 equally weighted symptom items. Participants report the severity of each symptom and symptom impact at its worst using a 4-point verbal rating scale (0-None to 3-Severe). Participants are asked to report their experience with nasal polyposis symptoms (nasal blockage, nasal congestion, runny nose, postnasal drip (mucus drainage down the throat), headache, facial pain, facial pressure, difficulty with sense of smell) and symptom impacts (difficulty with sleeping due to nasal symptoms and difficulty with daily activities due to nasal symptoms). The participant is asked to consider their experience with nasal polyposis/nasal polyps over the past 24hrs when responding to each question. The participant will complete an 11-item nasal polyposis symptom diary each morning throughout the screening, treatment and followup periods. ![]() Why Should I Register and Submit Results?Ĭhange from baseline in bi-weekly mean Nasal Polyposis Symptom Diary Total Symptom Score at Week 52.
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